Welcome

Biointerface group picture

CSU represented at the Biointerface 2018 Workshop & Symposium in Boulder, CO - October 2018.

 

Our research interests are in the study and development of advanced biocompatible materials. In most clinical applications, the introduction of a foreign material can lead to serious health risks and undesirable complications such as infection, blood clotting, and tissue growth. In our lab, we focus on synthesizing materials and artificial surfaces that replicate the natural function of endothelial cells through the release of nitric oxide (NO). These materials can effectively reduce or completely inhibit the complications associated with biologically-implanted materials. The current focus in our lab is on designing and developing biodegradable NO polymers, investigating the role of NO in cellular-material interactions, and engineering NO microdevices with the capability of controlling NO delivery dosages.

Nitric oxide MOF image

News and Updates

Group News

Group Picture August 2017
Group Picture: August 2017 (New Chemistry Research Building Lab!)

Funding and Award News

Recent Select Publications

Examining the Effect of Common Nitrosating Agents on Chitosan Using a Glucosamine Oligosaccharide Model System. Carbohydrate Polymers. 2018, 203, 285-291.

Cell-based Methods for Determination of Efficacy for Candidate Therapeutics in the Clinical Management of Cancer. Diseases. 2018, 6(4), 85.

Nitric Oxide-Mediated Fibrinogen Deposition Prevents Platelet Adhesion and Activation. Biointerphases. 2018, 13, 06E403. **Invited for special edition and selected as a feature article**

Biodegradable Crosslinked Polyesters Derived from Thiomalic Acid and S-nitrosothiol Analogues for Nitric Oxide Release. J. Mater. Chem. B. 2018, 6, 4071–4081. **Selected for cover art**

Neufeld, B. H.; Tapia, J. B.; Lutzke, A.; Reynolds, M. M. Small Molecule Interferences in Resazurin and MTT-Based Metabolic Assays in the Absence of Cells. ACS Anal. Chem. 2018, 90(11), 6867–6876.

Surface-Anchored Metal Organic Framework Cotton Material for Tunable Antimicrobial Copper Delivery. ACS Appl. Mater. Interfaces. 2018, 10, 15189–15199.

Metal-Organic Framework/Chitosan Hybrid Materials Promote Nitric Oxide Release from S-Nitrosoglutathione in Aqueous Solution. ACS Appl. Mater. Interfaces 2017, 9(6), 5139-5148.

Sustained Nitric Oxide Release from a Tertiary S-Nitrosothiol-based Polyphosphazene Coating. ACS Appl. Mater. Interfaces. 2017, 9(3), 2104-2113.

Nitric Oxide Release from a Biodegradable Cysteine-based Polyphosphazene.J. Mater. Chem. B. 2016,4,1987-1998.

Study of Polydiacetylene-Poly (Ethylene Oxide) Electrospun Fibers Used as Biosensors.Materials. 2016,9(3), 202.(Invited)

Research Funding

NIH logo

NSF logo

Boettcher logo

DOD logo

OEDIT logo

CSU logo

Contact

E-mail

Melissa.Reynolds@colostate.edu

Mailing Address

Department of Chemistry
Colorado State University
Fort Collins, CO 80523

Telephone

Office: 970-491-3775
Fax: 970-491-1801