CSU represented at the Biointerface 2018 Workshop & Symposium in Boulder, CO - October 2018.
Our research interests are in the study and development of advanced biocompatible materials. In most clinical applications, the introduction of a foreign material can lead to serious health risks and undesirable complications such as infection, blood clotting, and tissue growth. In our lab, we focus on synthesizing materials and artificial surfaces that replicate the natural function of endothelial cells through the release of nitric oxide (NO). These materials can effectively reduce or completely inhibit the complications associated with biologically-implanted materials. The current focus in our lab is on designing and developing biodegradable NO polymers, investigating the role of NO in cellular-material interactions, and engineering NO microdevices with the capability of controlling NO delivery dosages.
News and Updates
- The group is presenting their research at Biointerface 2018 - a medical device meeting.
- Congratulations to Chris and Alec on their paper on the nitrosation of chitosan in Carbohydrate Polymers.
- Congratulations to Heather Rubin on defending her PhD.
- Jenna and the Brown group publish on analytical methods to determine effectiveness of cancer treatments. Congrats!
- Congratulations to Pam Yapor on defending her PhD.
- Yanyi and the Popat group publish on biodegradable crosslinked polyesters for nitric oxide release. Congrats!
- Pam, Bella and Jesus's work on biodegradable polymers to treat infection was highlighted on the cover of the Journal of Materials Chemistry B. Congrats!
- Congratulations to our graduating seniors - Joe Staver (Chemical and Biological Engineering) and Lindsey Paricio (Chemistry). We wish you the best!
- Bella, Jesus and Alec's Analytical Chemistry paper on small molecule interferences in resazurin and MTT-based metabolic assays in the absence of cells was accepted. Congrats!
- Heather Rubin and Bella Neufeld report on tunable MOFs as antibacterials. Congrats!
- Alyssa Melvin was selected for a NSF GAUSSI fellowship. Congrats!
Group Picture: August 2017 (New Chemistry Research Building Lab!)
Funding and Award News
- Prof. Reynolds and Dr. Batchinsky of the U.S. Army Institute of Surgical Research were awarded a $3.4 million DoD award to improve breathing for critically ill patients
- Reynolds lab receives $1.4 million NIH grant to develop MOF-based catheters in collaboration with Prof. Handa from the University of Georgia.
- Prof. Reynolds named 2017 Professor Laureate by the College of Natural Sciences for outstanding contributions to research, teaching, mentoring, and outreach.
- Prof. Reynolds was awarded a Monfort Professorship. The award includes research support for fundamental and applied studies focused on metal-organic framework materials as anti-platelet and anti-bacterial agents.
- Advanced Industries Accelerator has provided funding for biological MOF studies.
- Prof. Borlee and Prof. Reynolds were awarded funding to study biofilm dispersion.
- Professors Kipper, Krapf, Li and Reynolds were awarded a collaborative NSF-CBET grant to study protein adsorption in polysaccharide brushes.
- Prof. Reynolds and her research group are members of two multidiscplinary teams that have received $200,000 in seed funding from the Catalyst for Innovative Partnerships (CIP) program.
- Professors Melissa Reynolds and Richard Finke have been awarded a collaborative NIH grant: Catalytic Nitric Oxide Release Coatings for Prolonged Anticlotting Catheters.
Recent Select Publications
Examining the Effect of Common Nitrosating Agents on Chitosan Using a Glucosamine Oligosaccharide Model System. Carbohydrate Polymers. 2018, 203, 285-291.
Nitric Oxide-Mediated Fibrinogen Deposition Prevents Platelet Adhesion and Activation. Biointerphases. 2018, 13, 06E403. **Invited for special edition and selected as a feature article**
Biodegradable Crosslinked Polyesters Derived from Thiomalic Acid and S-nitrosothiol Analogues for Nitric Oxide Release. J. Mater. Chem. B. 2018, 6, 4071–4081. **Selected for cover art**
Neufeld, B. H.; Tapia, J. B.; Lutzke, A.; Reynolds, M. M. Small Molecule Interferences in Resazurin and MTT-Based Metabolic Assays in the Absence of Cells. ACS Anal. Chem. 2018, 90(11), 6867–6876.
Surface-Anchored Metal Organic Framework Cotton Material for Tunable Antimicrobial Copper Delivery. ACS Appl. Mater. Interfaces. 2018, 10, 15189–15199.
Metal-Organic Framework/Chitosan Hybrid Materials Promote Nitric Oxide Release from S-Nitrosoglutathione in Aqueous Solution. ACS Appl. Mater. Interfaces 2017, 9(6), 5139-5148.
Sustained Nitric Oxide Release from a Tertiary S-Nitrosothiol-based Polyphosphazene Coating. ACS Appl. Mater. Interfaces. 2017, 9(3), 2104-2113.
Nitric Oxide Release from a Biodegradable Cysteine-based Polyphosphazene.J. Mater. Chem. B. 2016,4,1987-1998.
Study of Polydiacetylene-Poly (Ethylene Oxide) Electrospun Fibers Used as Biosensors.Materials. 2016,9(3), 202.(Invited)
Department of Chemistry
Colorado State University
Fort Collins, CO 80523