Welcome

Biointerface group picture

CSU represented at the Biointerface 2018 Workshop & Symposium in Boulder, CO - October 2018.

 

Our research interests are broadly defined within three distinct areas:

  • Development and synthesis of new biomedical materials
  • Applied and fundamental studies of Metal-Organic Frameworks (MOFs)
  • Analytical method development
Biomedical materials development includes the synthesis of prodrugs to simultaneously detect and kill bacteria, glucose biosensing, fabrication of biomass-sourced and biodegradable nitric oxide (NO) releasing polymers, the creation of new pediatric cancer therapeutics, and the creation of new materials to improve extracorporeal membrane oxygenation (ECMO). Applied areas of MOF research include the development of next-generation glucose biosensing, fluorescence-based sensing of heavy metals, incorporation of MOFs into biocompatible medical devices, and MOF-based high-performance liquid chromatography (HPLC) separations. Fundamental areas of MOF research include thermal/materials analysis of MOF catalysts, development of flow catalysis systems with MOFs, and kinetic/mechanistic investigations into MOF biocatalysis. Current projects related to analytical method development include generation of liquid chromatography-mass spectrometry (LC-MS) separation and detection methods to analyze the safety and biocompatibility of biodegradable medical devices, fast and easy LC-MS based detection methods for fungal infection biomarkers, and MOF based HPLC separations.

Nitric oxide MOF image

News and Updates

Group News

Group Picture August 2017
Group Picture: August 2017 (New Chemistry Research Building Lab!)

Funding and Award News

Recent Select Publications

Amino-Incorporated Tricarboxylate Metal–Organic Framework for the Sensitive Fluorescence Detection of Heavy Metal Ions with Insights into the Origin of Photoluminescence Response. Inorg. Chem. 2019 (articles asap).

Combined influence of nitric oxide and surface roughness in biofilm reduction across bacteria strains. Biointerphases. 2019, 14, 021004.

Study on microstructure and mechanical properties of polydiacetylene composite biosensors. J. Appl. Polym. Sci. 2019, 136, 47877.

Nitric oxide-releasing emulsion with hyaluronic acid and vitamin E. RSC Advances. 2019, 9, 21873 - 21880.

Copper ion vs copper metal–organic framework catalyzed NO release from bioavailable S-Nitrosoglutathione en route to biomedical applications: Direct 1H NMR monitoring in water allowing identification of the distinct, true reaction stoichiometries and thiol dependencies. J. Inorg. Biochem. 2019, 199, 110760.

Combined influence of nitric oxide and surface roughness in biofilm reduction across bacteria strains. Biointerphases. 2019, 14(2), 021004. **Featured on twitter @Biointerphases**

Fluorescent nitric oxide donor for the detection and killing of Pseudomonas aeruginosa. J. Mater. Chem. B. 2019, 7, 2009-2018.**Inside cover feature** Journal of Materials Chemistry B Journal Cover image

Nitric oxide generation from S-nitrosoglutathione: New activity of indium and a survey of metal ion effects. Nitric Oxide. 2019, 84, 16-21.

Examining the Effect of Common Nitrosating Agents on Chitosan Using a Glucosamine Oligosaccharide Model System. Carbohydrate Polymers. 2019, 203, 285-291.

Cell-based Methods for Determination of Efficacy for Candidate Therapeutics in the Clinical Management of Cancer. Diseases. 2018, 6(4), 85.

Nitric Oxide-Mediated Fibrinogen Deposition Prevents Platelet Adhesion and Activation. Biointerphases. 2018, 13, 06E403. **Invited for special edition and selected as a feature article**

Biodegradable Crosslinked Polyesters Derived from Thiomalic Acid and S-nitrosothiol Analogues for Nitric Oxide Release. J. Mater. Chem. B. 2018, 6, 4071–4081. **Selected for cover art**

Neufeld, B. H.; Tapia, J. B.; Lutzke, A.; Reynolds, M. M. Small Molecule Interferences in Resazurin and MTT-Based Metabolic Assays in the Absence of Cells. ACS Anal. Chem. 2018, 90(11), 6867–6876.

Surface-Anchored Metal Organic Framework Cotton Material for Tunable Antimicrobial Copper Delivery. ACS Appl. Mater. Interfaces. 2018, 10, 15189–15199.

Research Funding

NIH logo

NSF logo

Boettcher logo

DOD logo

OEDIT logo

CSU logo

Contact

E-mail

Melissa.Reynolds@colostate.edu

Mailing Address

Department of Chemistry
Colorado State University
Fort Collins, CO 80523

Telephone

Office: 970-491-3775
Fax: 970-491-1801