Reynolds and Kipper group members at the 33rd Annual Children's National Symposium on ECMO and Advanced Therapies for Respiratory Failure in Keystone, CO - February 2017. Pictured (left to right): Pam Yapor, Joe Staver, Heather Rubin, Yanyi Zang, Dr. Melissa Reynolds, Bella Neufeld, Dr. Matt Kipper, and Hasan Hedayati.
Our research interests are in the study and development of advanced biocompatible materials. In most clinical applications, the introduction of a foreign material can lead to serious health risks and undesirable complications such as infection, blood clotting, and tissue growth. In our lab, we focus on synthesizing materials and artificial surfaces that replicate the natural function of endothelial cells through the release of nitric oxide (NO). These materials can effectively reduce or completely inhibit the complications associated with biologically-implanted materials. The current focus in our lab is on designing and developing biodegradable NO polymers, investigating the role of NO in cellular-material interactions, and engineering NO microdevices with the capability of controlling NO delivery dosages.
News and Updates
- Heather Rubin reports on the functionalization of metal–organic frameworks to achieve controllable wettability in Inorganic Chemistry.
- Jesus Tapia will be presenting his work on multiple proton adduct ionization of polysaccharides using ESI-TOF mass spectrometry at the 65th ASMS Conference this June.
- Dr. Reynolds has been invited to teach 2017 summer courses at Shanghai Jiao Tong University, China.
- Congratulations to Megan, Alec, and Jesus on the publication of their MOF/Chitosan paper.
- Congratulations to Alec, Jesus, and Megan on the publication of their extended NO-release polyphosphazenes.
- Congratulations to Bella on her pseudomonas aeruginosa reduction paper.
- Undergraduate students Lindsey Paricio and Joe Staver will be presenting their research at the 253rd ACS National Meeting in San Francisco in April.
- The group will be participating and presenting in the 33rd Annual ECMO and Advanced Therapies for Respiratory Failure Conference in Keystone, CO at the end of February. This event will bring together clinicians, scientists, and engineers in translational discussions about anticlotting therapies.
- The group welcomes first year chemistry graduate students - Jenna Gordon and Rob Tuttle!
Dr. Melissa Reynolds, 2017 Monfort Professor awardee
Funding and Award News
- Prof. Reynolds named 2017 Professor Laureate by the College of Natural Sciences for outstanding contributions to research, teaching, mentoring, and outreach.
- Prof. Reynolds was awarded a Monfort Professorship. The award includes research support for fundamental and applied studies focused on metal-organic framework materials as anti-platelet and anti-bacterial agents.
- Advanced Industries Accelerator has provided funding for biological MOF studies.
- Prof. Borlee and Prof. Reynolds were awarded funding to study biofilm dispersion.
- Professors Kipper, Krapf, Li and Reynolds were awarded a collaborative NSF-CBET grant to study protein adsorption in polysaccharide brushes.
- Dr. Reynolds and her research group are members of two multidiscplinary teams that have received $200,000 in seed funding from the Catalyst for Innovative Partnerships (CIP) program.
- Professors Melissa Reynolds and Richard Finke have been awarded a collaborative NIH grant: Catalytic Nitric Oxide Release Coatings for Prolonged Anticlotting Catheters.
- Dr. Reynolds has been awarded an NSF CAREER grant: Metal Organic Frameworks for Increased Nitric Oxide Duration at Medical Interfaces Plus the Development of a Biomaterials Module for Non-STEM Majors".
- Dr. Reynolds received a grant from the Infectious Disease Supercluster.
- Dr. Reynolds was awarded the Educator of the Year by the Colorado Bioscience Association.
- Dr. Reynolds has been awarded a $1.3M DMRDP Basic Research Award from the Department of Defense. This was a highly competitive award with a 3.7% funding rate.
- Dr. Reynolds was named one of six inaugural Boettcher Investigators with the Webb-Waring Biomedical Research Program.
- Dr. Reynolds received a second grant from the State of Colorado Office of Economic Development and International Trade (OEDIT).
Recent Select Publications
Metal-Organic Framework/Chitosan Hybrid Materials Promote Nitric Oxide Release from S-Nitrosoglutathione in Aqueous Solution. ACS Appl. Mater. Interfaces 2017, 9(6), 5139-5148.
Sustained Nitric Oxide Release from a Tertiary S-Nitrosothiol-based Polyphosphazene Coating. ACS Appl. Mater. Interfaces. 2017, 9(3), 2104-2113.
Nitric Oxide Release from a Biodegradable Cysteine-based Polyphosphazene.J. Mater. Chem. B. 2016,4,1987-1998.
Study of Polydiacetylene-Poly (Ethylene Oxide) Electrospun Fibers Used as Biosensors.Materials. 2016,9(3), 202.(Invited)
Biodegradable Citrate-Based Polyesters with S-Nitrosothiol Functional Groups for Nitric Oxide Release. J. Mater. Chem. B. 2015, 3, 9233-9241. **Cover feature**
Immobilization of Metal-Organic Framework Copper(II) Benzene-1,3,5-Tricarboxylate (CuBTC) onto Cotton Fabric as a Nitric Oxide Release Catalyst. ACS Appl. Mater. Interfaces. 2015, 7, 26742–26750.
Nitric Oxide Releasing Polysaccharide Derivative Exhibits 8-log Reduction against Escherichia coli, Acinetobacter baumannii and Staphylococcus aureus. J. Controlled Release. 2015, 217, 228 – 234. (Invited)
A Tunable, Stable and Bioactive MOF for Generating a Localized Therapeutic from Endogenous Sources. Adv. Func. Mater. 2014, 24, 7503-7509.
Accurate Nitric Oxide Measurements from Donors in Cell Media: Identification of Scavenging Agents. Anal. Chem. 2014, 86(4), 2025-2032.
Composite Materials with Embedded Metal Organic Framework Catalysts for Nitric Oxide Release from Bioavailable S-nitrosothiols. J. Mater. Chem. B. 2014, 2, 2530-2536. (Invited; 2014 Emerging Investigator Issue)
The Relative Role of Soluble Guanylyl Cylase Dependent and Independent Pathways in Nitric Oxide Inhibition of Platelet Aggregation Under Flow. Cellular and Molecular Bioengineering, 2014, 7(3), 421-431.
Department of Chemistry
Colorado State University
Fort Collins, CO 80523