Welcome

ECMO conference group picture

Reynolds and Kipper group members at the 33rd Annual Children's National Symposium on ECMO and Advanced Therapies for Respiratory Failure in Keystone, CO - February 2017. Pictured (left to right): Pam Yapor, Joe Staver, Heather Rubin, Yanyi Zang, Dr. Melissa Reynolds, Bella Neufeld, Dr. Matt Kipper, and Hasan Hedayati.

Our research interests are in the study and development of advanced biocompatible materials. In most clinical applications, the introduction of a foreign material can lead to serious health risks and undesirable complications such as infection, blood clotting, and tissue growth. In our lab, we focus on synthesizing materials and artificial surfaces that replicate the natural function of endothelial cells through the release of nitric oxide (NO). These materials can effectively reduce or completely inhibit the complications associated with biologically-implanted materials. The current focus in our lab is on designing and developing biodegradable NO polymers, investigating the role of NO in cellular-material interactions, and engineering NO microdevices with the capability of controlling NO delivery dosages.

Nitric oxide MOF image

News and Updates

Group News

Group Picture August 2017
Group Picture: August 2017 (New Chemistry Research Building Lab!)

Funding and Award News

Recent Select Publications

Metal-Organic Framework/Chitosan Hybrid Materials Promote Nitric Oxide Release from S-Nitrosoglutathione in Aqueous Solution. ACS Appl. Mater. Interfaces 2017, 9(6), 5139-5148.

Sustained Nitric Oxide Release from a Tertiary S-Nitrosothiol-based Polyphosphazene Coating. ACS Appl. Mater. Interfaces. 2017, 9(3), 2104-2113.

Nitric Oxide Release from a Biodegradable Cysteine-based Polyphosphazene.J. Mater. Chem. B. 2016,4,1987-1998.

Study of Polydiacetylene-Poly (Ethylene Oxide) Electrospun Fibers Used as Biosensors.Materials. 2016,9(3), 202.(Invited)

Biodegradable Citrate-Based Polyesters with S-Nitrosothiol Functional Groups for Nitric Oxide Release. J. Mater. Chem. B. 2015, 3, 9233-9241. **Cover feature**

Immobilization of Metal-Organic Framework Copper(II) Benzene-1,3,5-Tricarboxylate (CuBTC) onto Cotton Fabric as a Nitric Oxide Release Catalyst. ACS Appl. Mater. Interfaces. 2015, 7, 26742–26750.

Nitric Oxide Releasing Polysaccharide Derivative Exhibits 8-log Reduction against Escherichia coli, Acinetobacter baumannii and Staphylococcus aureus. J. Controlled Release. 2015, 217, 228 – 234. (Invited)

A Tunable, Stable and Bioactive MOF for Generating a Localized Therapeutic from Endogenous Sources. Adv. Func. Mater. 2014, 24, 7503-7509.

Accurate Nitric Oxide Measurements from Donors in Cell Media: Identification of Scavenging Agents. Anal. Chem. 2014, 86(4), 2025-2032.

Composite Materials with Embedded Metal Organic Framework Catalysts for Nitric Oxide Release from Bioavailable S-nitrosothiols. J. Mater. Chem. B. 2014, 2, 2530-2536. (Invited; 2014 Emerging Investigator Issue)

The Relative Role of Soluble Guanylyl Cylase Dependent and Independent Pathways in Nitric Oxide Inhibition of Platelet Aggregation Under Flow. Cellular and Molecular Bioengineering, 2014, 7(3), 421-431.

Research Funding

NIH logo

NSF logo

Boettcher logo

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Contact

E-mail

Melissa.Reynolds@colostate.edu

Mailing Address

Department of Chemistry
Colorado State University
Fort Collins, CO 80523

Telephone

Office: 970-491-3775
Fax: 970-491-1801